The Newcastle upon Tyne Hospitals NHS Foundation Trust

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Details

Newcastle NHS Highly Specialised Service for Rare Mitochondrial Disorders, 4th Floor, Cookson Building, The Medical School, Newcastle University, Framlington Place
Framlington Place NE2 4HH , United Kingdom

Accreditation

Active UKAS 9027
+44 (0)191 2820848
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Accreditation Details

Accreditation Body

UKAS

Number

9027

Status

Active

Accreditation is granted under EU Regulation 765/2008 and assessed against ISO/IEC 17025. Data sourced from official UKAS records.

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Other locations

The Newcastle upon Tyne Hospitals NHS Foundation Trust Times Square The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne The Newcastle upon Tyne Hospitals NHS Foundation Trust High Heaton

Test Capabilities (27)
Standard Reference Description Category
Preparation of frozen tissue sections for histopathological and histochemical assessment of mitochondrial function Preparation of frozen tissue sections for histopathological and histochemical assessment of mitochondrial function Histopathology / Cytology
Staining of prepared tissue for the purposes of histological and enzyme histochemical analysis to aid diagnosis of mitochondrial genetic disease Staining of prepared tissue for the purposes of histological and enzyme histochemical analysis to aid diagnosis of mitochondrial genetic disease Histopathology / Cytology
Analysis of potential splicing variants Analysis of potential splicing variants Molecular Diagnostics / PCR
Detection of Large-scale mtDNA rearrangements Detection of Large-scale mtDNA rearrangements Molecular Diagnostics / PCR
Detection of known SNVs and indels mtDNA depletion mtDNA Deletions Detection of known SNVs and indels mtDNA depletion mtDNA Deletions Molecular Diagnostics / PCR
Detection of known or unknown sequence variants – SNVs, indels, and splicing variants Detection of known or unknown sequence variants – SNVs, indels, and splicing variants Molecular Diagnostics / PCR
Gene screening of large gene panels and mtDNA for genetic variants Gene screening of large gene panels and mtDNA for genetic variants Molecular Diagnostics / PCR
Generation of cDNA by reverse transcriptase for subsequent in- house analysis (see below) Generation of cDNA by reverse transcriptase for subsequent in- house analysis (see below) Molecular Diagnostics / PCR
Genomics analysis for the purpose of clinical diagnosis of mitochondrial disorders Genomics analysis for the purpose of clinical diagnosis of mitochondrial disorders Molecular Diagnostics / PCR
Molecular Genetics Molecular Genetics Molecular Diagnostics / PCR
SNVs, small indels SNVs, small indels Molecular Diagnostics / PCR
10μm tissue section, relating findings to a mitochondrial mass marker 10μm tissue section, relating findings to a mitochondrial mass marker Other
Axio Cam MRC-ZEIZZ Microscope Axio Cam MRC-ZEIZZ Microscope Other
Biochemical measurement of mitochondrial respiratory chain enzyme activities for (including combinations): Citrate synthase Biochemical measurement of mitochondrial respiratory chain enzyme activities for (including combinations): Citrate synthase The complex enzyme activity is calculated based on the Respiratory chain complex I measurement of the absorbance change during the biochemistry Respiratory chain complex II oxidoreductase reaction, then the activity is expressed as the ratio by Respiratory chain complex III dividing with citrate synthase activity Respiratory chain complex IV Using In house procedures: Preparation of Mitochondrial Fractions – fibroblasts and myoblasts MDS91 Preparation of Mitochondrial Fractions – skeletal or cardiac muscle MDS94 Preparation of Mitochondrial Fractions – pig heart muscle MDS93 Biochemical assay of Citrate Synthase MDS80 Biochemical assay of respiratory chain complex I activity MDS82 Biochemical assay of respiratory chain complex II activity MDS86 Biochemical assay of respiratory chain complex III MDS88 Biochemical assay of respiratory chain IV complex MDS90 Other
Enzyme histochemistry/histology Enzyme histochemistry/histology Other
MDS508 MDS508 Other
Mitochondrial Disorders Mitochondrial Disorders Other
Mitochondrial, genomic and nuclear Mitochondrial, genomic and nuclear Other
OXPHOS protein abundance in individual muscle fibres within a OXPHOS protein abundance in individual muscle fibres within a Other
Preparative pre-examination steps listed first Preparative pre-examination steps listed first Other
Quadruple Immunofluorescence Quadruple Immunofluorescence Other
Quantitative measurements of key Quantitative measurements of key Other
Respiratory Chain enzyme measurements Respiratory Chain enzyme measurements Other
Respiratory chain complex I Respiratory chain complex I Other
Respiratory chain complex II Respiratory chain complex II Other
Respiratory chain complex III Respiratory chain complex III Other
Respiratory chain complex IV Respiratory chain complex IV Other

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